Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke: A Randomized Clinical Trial

JAMA Neurol, February 2016 Importance Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of treatment delay on treatment effect is not yet known. Objective To evaluate the influence of time from stroke onset to the start of […]

Health care professionals’ views of the factors influencing the decision to refer patients to a stroke rehabilitation trial

Trials, 18 December 2015 Background Effective recruitment is an essential element of successful research but notoriously difficult to achieve. This article examines health care professionals’ views on the factors influencing decision-making regarding referral to a stroke rehabilitation trial. … Conclusions Patient- and professional-related factors were the most frequent influence on clinicians’ recruitment decisions, which often had a ‘gate-keeping’ […]

A Multicomponent Behavioral Intervention to Reduce Stroke Risk Factor Behaviors: The Stroke Health and Risk Education Cluster-Randomized Controlled Trial

Stroke, 1 October 2015 Background and Purpose—The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. … Conclusions—This multicomponent behavioral intervention targeting stroke risk factors in predominantly Hispanics/Latinos was effective in increasing fruit and vegetable intake, reaching its […]

Management of Central Poststroke Pain: Systematic Review of Randomized Controlled Trials

Stroke, 1 October 2015 Background and Purpose—Central poststroke pain is a chronic neuropathic disorder that follows a stroke. Current research on its management is limited, and no review has evaluated all therapies for central poststroke pain. … Conclusions—Our findings are inconsistent with major clinical practice guidelines; the available evidence suggests no beneficial effects of any therapies that researchers […]

Routing Ambulances to Designated Centers Increases Access to Stroke Center Care and Enrollment in Prehospital Research

Stroke, 1 October 2015 Background and Purpose—Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. … Conclusions—The establishment of a regionalized emergency medical services system of acute stroke care dramatically increased the proportion of patients […]

Long-Term Antiplatelet Mono- and Dual Therapies After Ischemic Stroke or Transient Ischemic Attack: Network Meta-Analysis

J Am Heart Assoc, 24 August 2015 Background The latest guidelines do not make clear recommendations on the selection of antiplatelet therapies for long-term secondary prevention of stroke. We aimed to integrate the available evidence to create hierarchies of the comparative efficacy and safety of long-term antiplatelet therapies after ischemic stroke or transient ischemic attack. … Conclusions Long-term […]

Examining Barriers and Practices to Recruitment and Retention in Stroke Clinical Trials

Stroke, 16 July 2015 Background and Purpose—The National Institutes of Health policy calls for the inclusion of under-represented groups, such as women and minorities, in clinical research. Poor minority recruitment and retention in stroke clinical trials remain a significant challenge limiting safety and efficacy in a general population. Previous research examines participant barriers to clinical […]

Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke

Stroke, 9 July 2015 Background and Purpose—It is unknown whether women and men with acute ischemic stroke respond similar to an antioxidant regimen administered in combination with thrombolysis. Here, we investigated the independent effect of sex on the response to uric acid (UA) therapy in patients with acute stroke treated with alteplase.… Conclusions—In women with […]

Clinical and Cost-Effectiveness of a System of Longer-Term Stroke Care

Stroke, 7 July 2015 Background and Purpose—We developed a new postdischarge system of care comprising a structured assessment covering longer-term problems experienced by patients with stroke and their carers, linked to evidence-based treatment algorithms and reference guides (the longer-term stroke care system of care) to address the poor longer-term recovery experienced by many patients with […]

Comparison of Acute Stroke Preparedness Strategies to Decrease Emergency Department Arrival Time in a Multiethnic Cohort: The Stroke Warning Information and Faster Treatment Study

Stroke, 11 June 2015 Background and Purpose—Less than 25% of stroke patients arrive to an emergency department within the 3-hour treatment window. Stroke Warning Information and Faster Treatment (SWIFT) compared an interactive intervention (II) with enhanced educational (EE) materials on recurrent stroke arrival times in a prospective cohort of multiethnic stroke/transient ischemic attack survivors.… Conclusions—There […]

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